**************** DOCTYPE=GENRX; ELEMENT=DRUG **************** 002444 Warfarin Sodium Warfarin-S 96/04/11DuPont Pharma 95/096386-0195/09 NICOLE ALEXANDER 96/04/11DuPont Pharma95/09 6386-0295/09 Anticoagulants Anticoagulants/Thrombolytics Atrial Fibrillation Blood Formation/Coagulation Coagulants and Anticoagulants Coronary Occlusion Embolism ... ********* DOCTYPE=INTERACTION; ELEMENT=INTERACTION-CLASS ********* d000249 d001047 d002444 ... Patients stabilized on an oral anti-coagulant are at a higher risk of developing bleeding complications if large IV doses of penicillin are also administered. This interaction may be due to a combined inhibition of ADP-induced platelet aggregation. This interaction is dose-dependent. ...